How I manage cold agglutinin disease.

Detection of Cold Agglutinin with Cross-Reactive Idiotype Produced by Pneumonie Patients

Problems of Cold Agglutinins in Cardiac Surgery: How to Manage Cardiopulmonary Bypass and Myocardial Protection

Cold agglutinins are of unique relevance in cardiac surgerybecause of the use of hypothermic cardiopulmonary bypass (CPB). Cold autoimmune diseases are defined by the presence of abnormal circulating proteins (usually IgM or IgA antibodies) that agglutinate in response to a decrease in body temperature. These disorders include cryoglobulinemia and cold hemagglutinin disease.Immunoglobulin M aut...

Cold agglutinin disease associated with mycoplasma infection in an individual with type 2 diabetes: An atypical case

Cold Agglutinin Disease is a hemolytic anemia associated with cold reactive autoantibodies. Although the acute form of cold agglutinin disease can be attributed to autoimmune or infectious diseases and lymphoproliferative diseases, it has,to the best of our knowledge, so far,never been reported as secondary to Mycoplasma pneumonia in a type 2 diabetic individual. In this paper, we report a case...

Glucocorticoid-Responsive Cold Agglutinin Disease in a Patient with Rheumatoid Arthritis

A 57-year-old man with rheumatoid arthritis developed severe anemia during treatment with adalimumab plus methotrexate. Cold agglutinin disease was diagnosed because haptoglobin was undetectable, cold agglutinin was positive (1 : 2048), and the direct Coombs test was positive (only to complement). Although the cold agglutinin titer was normalized (1 : 64) after treatment with prednisolone (0.7 ...

Lymphocytes forming red cell rosettes in the cold in patients with chronic cold agglutinin disease.

Lymphocytes that formed rosettes with sera made to the serum macroglobulins human red cells in the cold were observed detected the same proteins on the lymphoin the peripheral blood of four patients cyte surface. Evidence was obtained that with chronic cold agglutinin disease. Simthe rosette test underestimated the numilar rosettes were not observed in normals ber of cells bearing the specific ...